After a brief chase Timothy Sargent, 41, was caught near Sioux Falls, South Dekota, along with a 20-year-old woman by the name of Savanna Emich who was also taken into custody, said Indiana State Police.
The shootings took place in Indiana, Ohio, and West Virginia, and left two people dead and three others injured.
Akron police said Sargent was wanted for shooting and wounding a man Monday at a homeless camp. He was also suspected by Akron Police of fatally shooting 22-year-old Rebecca Tomlinson on Tuesday.
West Virginia State police wanted Sargent in the shooting death on Wednesday of a 62-year old man on a highway in Milton.
Indiana troopers said he and Emich were persons of interest in a roadside shooting in rural Harrison County that took place Wednesday night.
The victims of Wednesday were a Kentucky man, his wife, and their 16-year-old daughter who were on the road going home.
Troopers believe Sargent shot the couple after he flashed his high beams at their vehicle and the man pulled over.
The man and his wife were shot and he suffered life-threatening wounds, the troopers said. The teen who was in the back seat was not hurt.